ARHGEF5

ARHGEF5
Identifiers
Aliases	ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs	MGI: 1858952 HomoloGene: 66300 GeneCards: ARHGEF5
Gene ontology Molecular function • GTP binding • protein binding • lipid binding • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cell projection • plasma membrane • nucleoplasm • cell junction • podosome • nucleus • cell periphery • cytosol Biological process • intracellular signal transduction • regulation of actin cytoskeleton organization • positive regulation of JUN kinase activity • regulation of GTPase activity • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of podosome assembly • myeloid dendritic cell chemotaxis • positive regulation of GTPase activity • positive regulation of protein import • regulation of ERK1 and ERK2 cascade • regulation of Rho protein signal transduction • regulation of cytoskeleton organization • actin cytoskeleton organization • positive regulation of stress fiber assembly • positive regulation of apoptotic process • regulation of small GTPase mediated signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7984	54324
Ensembl	ENSG00000050327	ENSMUSG00000033542
UniProt	Q12774	E9Q7D5
RefSeq (mRNA)	NM_001002861 NM_005435	NM_133674
RefSeq (protein)	NP_005426	NP_598435
Location (UCSC)	Chr 7: 144.36 – 144.38 Mb	Chr 6: 43.27 – 43.29 Mb
PubMed search

7984

54324

ENSG00000050327

ENSMUSG00000033542

Q12774

E9Q7D5

NM_001002861
NM_005435

NM_133674

NP_005426

NP_598435

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.

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