ARHGEF6

ARHGEF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UJY, 1WYR
Identifiers
Aliases	ARHGEF6, COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX, Rac/Cdc42 guanine nucleotide exchange factor 6
External IDs	MGI: 1920591 HomoloGene: 3561 GeneCards: ARHGEF6
Gene ontology Molecular function • protein binding • GTPase activator activity • Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity Cellular component • cytosol • cell projection • intracellular • lamellipodium Biological process • positive regulation of apoptotic process • JNK cascade • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • lamellipodium assembly • apoptotic process • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9459	73341
Ensembl	ENSG00000129675	ENSMUSG00000031133
UniProt	Q15052	Q8K4I3
RefSeq (mRNA)	NM_001306177 NM_004840	NM_152801
RefSeq (protein)	NP_001293106 NP_004831	NP_690014
Location (UCSC)	Chr X: 136.67 – 136.78 Mb	Chr X: 57.23 – 57.34 Mb
PubMed search

1UJY, 1WYR

9459

73341

ENSG00000129675

ENSMUSG00000031133

Q15052

Q8K4I3

NM_001306177
NM_004840

NM_152801

NP_001293106
NP_004831

NP_690014

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that catalyse the exchange of GDP for GTP in some Rho-family small GTPases. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

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