ASIC2

ASIC2
Identifiers
Aliases	ASIC2, ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1, acid sensing ion channel subunit 2
External IDs	MGI: 1100867 HomoloGene: 137202 GeneCards: ASIC2
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2-q12 Start 33,013,087 bp End 34,174,964 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 48.43 cM Start 80,880,169 bp End 81,968,457 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion gated channel activity • sodium channel activity • ion channel activity • protein binding • cation channel activity • ligand-gated sodium channel activity • acid-sensing ion channel activity Cellular component • integral component of membrane • membrane • plasma membrane • dendritic spine • integral component of plasma membrane • synapse • neuronal cell body • neuron projection Biological process • chemical synaptic transmission • positive regulation of synapse assembly • peripheral nervous system development • sodium ion transmembrane transport • detection of mechanical stimulus involved in sensory perception • sodium ion transport • regulation of membrane potential • regulation of ion transmembrane transport • response to mechanical stimulus • negative regulation of apoptotic process • cation transport • sensory perception of sound • sensory perception of sour taste • ion transport • cation transmembrane transport • monovalent inorganic cation transport • central nervous system development • ion transmembrane transport • regulation of vasoconstriction • regulation of gene expression • regulation of blood coagulation • protein localization to synapse • response to acidic pH • phototransduction • regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	40	11418
Ensembl	ENSG00000108684	ENSMUSG00000020704
UniProt	Q16515	Q925H0
RefSeq (mRNA)	NM_183377 NM_001094	NM_001034013 NM_007384
RefSeq (protein)	NP_001085 NP_899233	NP_001029185 NP_031410
Location (UCSC)	Chr 17: 33.01 – 34.17 Mb	Chr 17: 80.88 – 81.97 Mb
PubMed search

40

11418

ENSG00000108684

ENSMUSG00000020704

Q16515

Q925H0

NM_183377
NM_001094

NM_001034013
NM_007384

NP_001085
NP_899233

NP_001029185
NP_031410

Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein that in humans is encoded by the ASIC2 gene. The ASIC2 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1996. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

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