ATF3

ATF3
Identifiers
Aliases	ATF3, activating transcription factor 3
External IDs	MGI: 109384 HomoloGene: 1265 GeneCards: ATF3
Gene ontology Molecular function • transcription regulatory region sequence-specific DNA binding • protein homodimerization activity • protein binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein heterodimerization activity • identical protein binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription regulatory region DNA binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • nucleolus • nucleoplasm • CHOP-ATF3 complex • nucleus Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • positive regulation of cell proliferation • skeletal muscle cell differentiation • regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance • gluconeogenesis • cellular response to amino acid starvation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of TRAIL-activated apoptotic signaling pathway • GO:0006350 transcription, DNA-templated • positive regulation of gene expression • PERK-mediated unfolded protein response • positive regulation of transcription from RNA polymerase II promoter • negative regulation of ERK1 and ERK2 cascade • negative regulation of transcription from RNA polymerase II promoter • endoplasmic reticulum unfolded protein response • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	467	11910
Ensembl	ENSG00000162772	ENSMUSG00000026628
UniProt	P18847	Q60765
RefSeq (mRNA)	NM_001030287 NM_001040619 NM_001206484 NM_001206485 NM_001206486 NM_001206488 NM_001674 NM_004024	NM_007498
RefSeq (protein)	NP_001025458 NP_001035709 NP_001193413 NP_001193415 NP_001193417 NP_001665	NP_031524
Location (UCSC)	Chr 1: 212.57 – 212.62 Mb	Chr 1: 191.17 – 191.22 Mb
PubMed search

467

11910

ENSG00000162772

ENSMUSG00000026628

P18847

Q60765

NM_001206488
NM_001674
NM_004024

NM_007498

NP_001665

NP_031524

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

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