ATP6V0A2

ATP6V0A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LX4
Identifiers
Aliases	ATP6V0A2, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS, ATPase H+ transporting V0 subunit a2
External IDs	MGI: 104855 HomoloGene: 56523 GeneCards: ATP6V0A2
Gene ontology Molecular function • ATPase binding • proton-transporting ATPase activity, rotational mechanism • protein binding • hydrogen ion transmembrane transporter activity Cellular component • integral component of membrane • endosome • proton-transporting V-type ATPase, V0 domain • phagocytic vesicle membrane • membrane • vacuolar proton-transporting V-type ATPase, V0 domain • lysosomal membrane • acrosomal vesicle • vacuolar proton-transporting V-type ATPase complex • endosome membrane • plasma membrane Biological process • insulin receptor signaling pathway • transferrin transport • vacuolar proton-transporting V-type ATPase complex assembly • ion transport • proton transport • vacuolar acidification • ion transmembrane transport • immune response • transport • ATP synthesis coupled proton transport • ATP hydrolysis coupled proton transport • regulation of macroautophagy • phagosome acidification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23545	21871
Ensembl	ENSG00000185344	ENSMUSG00000038023
UniProt	Q9Y487	P15920
RefSeq (mRNA)	NM_012463	NM_011596
RefSeq (protein)	NP_036595	NP_035726.2 NP_035726
Location (UCSC)	Chr 12: 123.71 – 123.76 Mb	Chr 5: 124.63 – 124.72 Mb
PubMed search

2LX4

23545

21871

ENSG00000185344

ENSMUSG00000038023

Q9Y487

P15920

NM_012463

NM_011596

NP_036595

NP_035726.2
NP_035726

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

V-ATPase 116 kDa isoform a2 is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase consists of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain.

Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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