Against All Odds (2008) was a professional wrestling pay-per-view (PPV) event produced by the Total Nonstop Action Wrestling (TNA) promotion, which took place on February 10, 2008 at the BI-LO Center in Greenville, South Carolina. It was the fourth event under the Against All Odds chronology and the second event in the 2008 TNA PPV schedule. Nine professional wrestling matches were featured on the event's card, four of which involved championships, while two matches were held prior to the event.

The main event was for the TNA World Heavyweight Championship with Samoa Joe as Special Outside Enforcer between then-champion Kurt Angle and the challenger Christian Cage. Angle ended up winning the bout, thus retaining the championship. Jay Lethal and The Motor City Machine Guns (Alex Shelley and Chris Sabin) fought Johnny Devine and Team 3D (Brother Devon and Brother Ray) in a Six Man Tag Team Street Fight on the card. Lethal and The Motor City Machine Guns won the encounter. A Barbed Wire Massacre between Abyss and Judas Mesias was held at Against All Odds, which Abyss won. Booker T fought Robert Roode to a double countout in another highly promoted match for the event.