The Agame (Tigrinya ዓጋመ ʿāgāme, Amharic ዓጋሜ āgāmē, "fruitful") is a former province in northern Ethiopia, now part of the Tigray Region. Its inhabitants include the Irob people, a region where tradition states the legendary Makeda (the Queen of Sheba) was born and raised. The aristocratic house had its capital at Adigrat.
Zalambessa is an area in Agame province that Ethiopia and Eritrea have recently fought over.
Agame is one of the oldest regions of Ethiopia, being part of the Kingdom of D'mt in northern Ethiopia and Eritrea that would develop into the Kingdom of Aksum.It was a main center of Aksumite culture (second only to Western Tigray, where the capital was located), with a distinct sub-culture that separated the two regions from that of Western Tigray (Shire, Axum, Yeha), Central Eritrea (Seraye, Hamasien, Akele Guzai and Adulis), and frontier areas in northern Eritrea. The first mention of Agame was in the Monumentum Adulitanum of the early 3rd century, where it is listed as one of the districts conquered by the unnamed king of the inscription; however, its next mention is not until the sixteenth century in a charter written during the reign of Emperor Lebna Dengel. During medieval times, Agame was part of a larger province of Bur in Ethiopia, which also included some northeastern Afar lowlands, and the Buri Peninsula; Agame and Akkele Guzay were part of "Upper" (La'ilay) Bur, while the lowlands were further distinguished as "Lower" (Tahtay).