Alpha-Mannosidase
| alpha-mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
alpha-mannosidase 1, tetramer, Saccharomyces cerevisiae
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| Identifiers | |||||||||
| EC number | 3.2.1.24 | ||||||||
| CAS number | 9025-42-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
| mannosidase, alpha, class 2B, member 1 | |
|---|---|
| Identifiers | |
| Symbol | MAN2B1 |
| Alt. symbols | MANB |
| Entrez | 4125 |
| HUGO | 6826 |
| OMIM | 609458 |
| RefSeq | NM_000528 |
| UniProt | O00754 |
| Other data | |
| EC number | 3.2.1.24 |
| Locus | Chr. 19 cen-q13.1 |
| mannosidase, alpha, class 2B, member 2 | |
|---|---|
| Identifiers | |
| Symbol | MAN2B2 |
| Alt. symbols | KIAA0935 |
| Entrez | 23324 |
| HUGO | 29623 |
| RefSeq | NM_015274 |
| UniProt | Q9Y2E5 |
| Other data | |
| EC number | 3.2.1.24 |
| Locus | Chr. 4 p16.2 |
| mannosidase, alpha, class 2C, member 1 | |
|---|---|
| Identifiers | |
| Symbol | MAN2C1 |
| Alt. symbols | MANA1, MANA |
| Entrez | 4123 |
| HUGO | 6827 |
| OMIM | 154580 |
| RefSeq | NM_006715 |
| UniProt | Q9NTJ4 |
| Other data | |
| EC number | 3.2.1.24 |
| Locus | Chr. 15 q11-qter |
alpha-Mannosidase (EC 3.2.1.24, alpha-D-mannosidase, p-nitrophenyl-alpha-mannosidase, alpha-D-mannopyranosidase, 1,2-alpha-mannosidase, 1,2-alpha-D-mannosidase, exo-alpha-mannosidase) is an enzyme involved in the cleavage of the alpha form of mannose. Its systematic name is alpha-D-mannoside mannohydrolase.
Humans express the following three alpha-mannosidase isozymes:
It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.
A deficiency can lead to alpha-mannosidosis.
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Wikipedia