Alpha-granules
| Alpha granule | |
|---|---|
| Details | |
| Identifiers | |
| Latin | granulum alpha |
| Code | TH H2.00.04.1.03005 |
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Anatomical terminology
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In platelets, the term "alpha granules" is used to describe granules containing several growth factors.
Contents include insulin-like growth factor 1, platelet-derived growth factors, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V, and von Willebrand factor).
The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
A deficiency of alpha granules is known as gray platelet syndrome.
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