Angiotensin-Converting Enzyme

Angiotensin-converting enzyme
Identifiers
EC number	3.4.15.1
CAS number	9015-82-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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PMC	articles
PubMed	articles
NCBI	proteins

ACE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O86, 1O8A, 1UZE, 1UZF, 2C6F, 2C6N, 2IUL, 2IUX, 2OC2, 2XY9, 2XYD, 2YDM, 3BKK, 3BKL, 3NXQ, 4APH, 4APJ, 3L3N, 4BXK, 4BZR, 4BZS, 4C2N, 4C2O, 4C2P, 4C2Q, 4C2R, 4CA5, 4CA6, 4UFA, 4UFB, 5AMB, 5AM9, 5AM8, 5AMC, 5AMA
Identifiers
Aliases	ACE, angiotensin I converting enzyme, ACE1, CD143, DCP, DCP1, ICH, MVCD3, Angiotensin-converting enzyme
External IDs	OMIM: 106180 MGI: 87874 HomoloGene: 37351 GeneCards: ACE
Targeted by Drug
captopril, cilazapril anhydrous, enalapril, imidapril, trandolapril, zofenopril
Gene ontology Molecular function • tripeptidyl-peptidase activity • zinc ion binding • exopeptidase activity • endopeptidase activity • metal ion binding • mitogen-activated protein kinase binding • bradykinin receptor binding • peptidase activity • protein binding • drug binding • carboxypeptidase activity • chloride ion binding • actin binding • mitogen-activated protein kinase kinase binding • hydrolase activity • metallodipeptidase activity • metallopeptidase activity • peptidyl-dipeptidase activity Cellular component • cytoplasm • integral component of membrane • endosome • membrane • lysosome • extracellular exosome • external side of plasma membrane • extracellular region • plasma membrane • extracellular space Biological process • regulation of renal output by angiotensin • antigen processing and presentation of peptide antigen via MHC class I • angiotensin catabolic process in blood • beta-amyloid metabolic process • angiotensin maturation • blood vessel remodeling • regulation of vasoconstriction • hematopoietic stem cell differentiation • regulation of angiotensin metabolic process • regulation of smooth muscle cell migration • mononuclear cell proliferation • regulation of systemic arterial blood pressure by renin-angiotensin • arachidonic acid secretion • peptide catabolic process • regulation of blood vessel diameter • kidney development • neutrophil mediated immunity • proteolysis • spermatogenesis • regulation of blood pressure • hormone catabolic process • heart contraction • positive regulation of protein tyrosine kinase activity • cell proliferation in bone marrow • positive regulation of peptidyl-tyrosine autophosphorylation • regulation of hematopoietic stem cell proliferation • negative regulation of gap junction assembly • positive regulation of peptidyl-cysteine S-nitrosylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1636	11421
Ensembl	ENSG00000159640	ENSMUSG00000020681
UniProt	P12821	P09470
RefSeq (mRNA)	NM_000789 NM_001178057 NM_152830 NM_152831	NM_009598 NM_207624 NM_001281819
RefSeq (protein)	NP_000780 NP_001171528 NP_690043	NP_033728.1 NP_997507.1 NP_001268748 NP_033728 NP_997507
Location (UCSC)	Chr 17: 63.48 – 63.5 Mb	Chr 11: 105.97 – 105.99 Mb
PubMed search

1O86, 1O8A, 1UZE, 1UZF, 2C6F, 2C6N, 2IUL, 2IUX, 2OC2, 2XY9, 2XYD, 2YDM, 3BKK, 3BKL, 3NXQ, 4APH, 4APJ, 3L3N, 4BXK, 4BZR, 4BZS, 4C2N, 4C2O, 4C2P, 4C2Q, 4C2R, 4CA5, 4CA6, 4UFA, 4UFB, 5AMB, 5AM9, 5AM8, 5AMC, 5AMA

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