Arrestin beta 1

ARRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IV8
Identifiers
Aliases	ARRB1, ARB1, ARR1, Arrestin beta 1
External IDs	MGI: 99473 HomoloGene: 2981 GeneCards: ARRB1
Gene ontology Molecular function • ion channel binding • GTPase activator activity • histone acetyltransferase activity • transcription regulatory region DNA binding • estrogen receptor binding • enzyme inhibitor activity • insulin-like growth factor receptor binding • transcription factor binding • follicle-stimulating hormone receptor binding • mitogen-activated protein kinase kinase binding • clathrin adaptor activity • protein phosphorylated amino acid binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • AP-2 adaptor complex binding • alpha-1B adrenergic receptor binding • V2 vasopressin receptor binding • phosphoprotein binding • angiotensin receptor binding • ubiquitin protein ligase binding • alpha-1A adrenergic receptor binding Cellular component • cytoplasm • cytosol • postsynaptic membrane • membrane • nucleus • cell projection • dendritic spine • heterotrimeric G-protein complex • chromatin • plasma membrane • intracellular • nucleoplasm • clathrin-coated pit • pseudopodium • postsynaptic density • Golgi membrane • lysosomal membrane • basolateral plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • nuclear body Biological process • positive regulation of Rho protein signal transduction • positive regulation of protein phosphorylation • regulation of G-protein coupled receptor protein signaling pathway • positive regulation of receptor internalization • transcription from RNA polymerase II promoter • stress fiber assembly • follicle-stimulating hormone signaling pathway • platelet activation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of GTPase activity • positive regulation of ERK1 and ERK2 cascade • positive regulation of insulin secretion involved in cellular response to glucose stimulus • proteasome-mediated ubiquitin-dependent protein catabolic process • phototransduction • regulation of transcription, DNA-templated • GO:0006350 transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • negative regulation of interleukin-8 production • protein ubiquitination • protein transport • negative regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of smooth muscle cell apoptotic process • activation of MAPK activity • positive regulation of histone H4 acetylation • transport • positive regulation of protein binding • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein ubiquitination • G-protein coupled receptor internalization • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • endocytosis • negative regulation of interleukin-6 production • positive regulation of histone acetylation • negative regulation of protein ubiquitination • negative regulation of ERK1 and ERK2 cascade • negative regulation of signal transduction • positive regulation of transcription from RNA polymerase II promoter • signal transduction • positive regulation of GTPase activity • apoptotic process • response to drug • membrane organization • regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	408	109689
Ensembl	ENSG00000137486	ENSMUSG00000018909
UniProt	P49407	Q8BWG8
RefSeq (mRNA)	NM_004041 NM_020251	NM_177231 NM_178220
RefSeq (protein)	NP_004032 NP_064647	NP_796205.1 NP_835738.1 NP_796205 NP_835738
Location (UCSC)	Chr 11: 75.26 – 75.35 Mb	Chr 7: 99.54 – 99.61 Mb
PubMed search

2IV8

408

109689

ENSG00000137486

ENSMUSG00000018909

P49407

Q8BWG8

NM_004041
NM_020251

NM_177231
NM_178220

NP_004032
NP_064647

NP_796205.1
NP_835738.1
NP_796205
NP_835738

Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. Beta-arrestin might also play a role as scaffold protein in the GPCR pathways.

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Wikipedia