Atypical fibroxanthoma

Atypical fibroxanthoma
Classification and external resources
Specialty	oncology, rheumatology
ICD-10	C49 (ILDS C49.M12)
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Atypical fibroxanthoma of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically.

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It occurs most commonly on the skin of sun-exposed, elderly patients. The majority of tumors are on the scalp, face, ears and upper limbs, but less commonly the tumor occurs on the limbs and trunk when there is a lack of association with sun exposure in younger individuals. The condition has also been noted in organ transplant recipients who may be in a state of immunosuppression. It has been reported that there is a predominance in men (70% men versus 30% women).

Tumour of skin/soft tissue

Common in the elderly

Differential diagnoses: Squamous cell carcinoma Malignant fibrous histiocytoma

Treatment: Surgical excision with clear margins

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