The Battle of Cherokee Station was a battle of the American Civil War fought between Union and Confederate forces near the Memphis and Charleston Railroad in Alabama on 21 October 1863.

On 20 October, a skirmish occurred between the 5th Ohio Cavalry and a large troop of Confederate cavalry. The 3rd U.S. Cavalry came up as support, but the 5th Cavalry finished off the Confederates on their own. The 5th lost a total of three men and two horses.

On 21 October at 08:00, the XV Corps moved up towards the location of the Confederate troops, with its 1st Division leading. They encountered a large force of Confederate soldiers and opened fire. Musket fire was exchanged for an hour, with the Confederates sustaining heavy losses. After the loss of a significant amount of their men, the Confederates retreated. The division brought up several 20-pound Parrott rifles and inflicted several dozen more casualties. Several Confederate soldiers were captured as well.

The Confederates retreated from the field back to fortifications near Tuscumbia. Union forces sustained 35 casualties, while the Confederates suffered 300-400 casualties.

Lee used artillery and his men to delay the Union’s assault on Tuscumbia and made occassional skirmishes with Union troops. However, on 27 October, Lee was forced to retreat from Tuscumbia. As Union troops went towards Georgia, Lee attempted a second assault on Cherokee Staion, but was repulsed by XV Corps. Several more skirmishes occurred in the next few days. Due to the lack of supplies, Lee was forced to withdraw from Alabama to northern Mississippi. Bragg commended Lee for his actions in delaying Union forces.

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