Bayou Plaquemine Brulé (/ˈplækᵻmɪn ˈbruːli/; historically spelled Plakemine; translated to "burnt persimmon bayou") is a waterway in the Mermentau River basin of south Louisiana. The bayou is 58 miles (93 km) long and is navigable for 19 miles (31 km) of its lower course.
One of the first settlers of the area was Michel Comeau.