Begum Kulsum Saifullah Khan (7 December 1924 – 26 January 2015) was a Pakistani businesswoman and politician. She was Chairperson of the Saif Group of companies from 1964 to 1990. She remained a parliamentarian and a federal minister in Pakistan in the 1980s.
She had five sons: Anwar Saifullah Khan, Salim Saifullah Khan, Humayun Saifullah Khan, Javed Saifullah Khan and Iqbal Saifullah Khan.
She was awarded the Hilal-i-Imtiaz by president Pervez Musharraf. She died in January 2015 aged 91.