Beta-mannosidase

beta-mannosidase
Identifiers
Aliases	MANBA, MANB1, mannosidase beta
External IDs	MGI: 88175 HomoloGene: 4317 GeneCards: MANBA
Gene ontology Molecular function • hydrolase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • mannose binding • hydrolase activity, acting on glycosyl bonds • beta-mannosidase activity Cellular component • lysosome • lysosomal lumen • plasma membrane • azurophil granule membrane • intracellular membrane-bounded organelle Biological process • metabolic process • cellular protein modification process • oligosaccharide catabolic process • neutrophil degranulation • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4126	110173
Ensembl	ENSG00000109323	ENSMUSG00000028164
UniProt	O00462	Q8K2I4
RefSeq (mRNA)	NM_005908	NM_027288
RefSeq (protein)	NP_005899	NP_081564.3 NP_081564
Location (UCSC)	Chr 4: 102.63 – 102.76 Mb	Chr 3: 135.49 – 135.57 Mb
PubMed search

Beta-mannosidase
Identifiers
EC number	3.2.1.25
CAS number	9025-43-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

4126

110173

ENSG00000109323

ENSMUSG00000028164

O00462

Q8K2I4

NM_005908

NM_027288

NP_005899

NP_081564.3
NP_081564

Beta-mannosidase (EC 3.2.1.25, mannanase, mannase, beta-D-mannosidase, beta-mannoside mannohydrolase, exo-beta-D-mannanase, lysosomal beta A mannosidase) is an enzyme with systematic name beta-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction

This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.

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Wikipedia