Blaine is an unincorporated community in northern Pease Township, Belmont County, Ohio, United States, along Wheeling Creek. Although it is unincorporated, it has a post office, with the ZIP code of 43909.
Blaine is part of the Wheeling, WV-OH Metropolitan Statistical Area.
The community was named after James G. Blaine.
Baseball Hall of Fame pitcher Phil Niekro was born in Blaine.
Coordinates: 40°04′04″N 80°49′02″W / 40.06778°N 80.81722°W