Coordinates: 44°58′43″N 93°16′29″W / 44.97861°N 93.27472°W
Mayo Clinic Square (formerly known as Block E) is the name of a block in downtown Minneapolis bounded by Hennepin Avenue, 6th Street, 7th Street, and 1st Avenue North. It is part of the Downtown West neighborhood in Minneapolis. It is one block south of the Warehouse District/Hennepin Avenue light rail station on the METRO Blue and Green lines.
The block has had a long history of different uses, from movie theaters and bars to retail and restaurants. Currently it is home to basketball practice facilities and front offices of both the Minnesota Timberwolves of the NBA and Minnesota Lynx of the WNBA. Mayo Clinic Square is connected to Target Center via the Minneapolis Skyway System. The building also contains a Mayo Clinic sports medicine facility, which is open to the public, and the street level redevelopment has been spearheaded with the new restaurant City Works.