Bradykinin receptor B1

BDKRB1
Identifiers
Aliases	BDKRB1, B1BKR, B1R, BDKRB2, BKB1R, BKR1, BRADYB1, Bradykinin receptor B1
External IDs	MGI: 88144 HomoloGene: 570 GeneCards: BDKRB1
Targeted by Drug
Bradykinin, kallidin
Gene ontology Molecular function • G-protein coupled receptor activity • peptide binding • signal transducer activity • protein binding • bradykinin receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • endoplasmic reticulum • neuron projection Biological process • negative regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • negative regulation of blood pressure • positive regulation of leukocyte migration • positive regulation of cytosolic calcium ion concentration • response to stress • response to mechanical stimulus • positive regulation of release of sequestered calcium ion into cytosol • response to lipopolysaccharide • protein kinase C-activating G-protein coupled receptor signaling pathway • negative regulation of cell growth • sensory perception of pain • inflammatory response • cell migration • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	623	12061
Ensembl	ENSG00000100739	ENSMUSG00000041347
UniProt	P46663	Q61125
RefSeq (mRNA)	NM_000710	NM_007539
RefSeq (protein)	NP_000701	NP_031565.1 NP_031565
Location (UCSC)	Chr 14: 96.26 – 96.27 Mb	Chr 12: 105.6 – 105.61 Mb
PubMed search

623

12061

ENSG00000100739

ENSMUSG00000041347

P46663

Q61125

NM_000710

NM_007539

NP_000701

NP_031565.1
NP_031565

Bradykinin receptor B1 (B₁) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B₁ receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B₁ protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.

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Wikipedia