Brush Creek is a stream in southern Laclede County in the U.S. state of Missouri. It is a tributary of the Osage Fork Gasconade River.
The stream headwaters arise about one mile northeast of Phillipsburg adjacent to I-44 at 37°33′51″N 92°47′01″W / 37.56417°N 92.78361°W. The stream flows southeast under I-44 and then generally east passing under Missouri Route C an then route PP north of Morgan. It continues east to its confluence with the Osage Fork about 1.5 miles west of Missouri Route 5 at 37°32′12″N 92°37′18″W / 37.53667°N 92.62167°WCoordinates: 37°32′12″N 92°37′18″W / 37.53667°N 92.62167°W.