Brush Creek is a 24.7-mile-long (39.8 km)tributary of the Raystown Branch Juniata River in Fulton and Bedford counties, Pennsylvania, in the United States.
Brush Creek flows down a valley between Polish Mountain and Rays Hill, and enters the Raystown Branch several miles west of Breezewood.
The Feltons Mill Covered Bridge and Jacksons Mill Covered Bridge cross Brush Creek.