Buclizine

Buclizine
Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	R06AE01 (WHO)
Identifiers
IUPAC name (RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
CAS Number	82-95-1^Y
PubChem CID	6729
IUPHAR/BPS	7134
DrugBank	DB00354^Y
ChemSpider	6473^Y
UNII	0C94V6X681
ChEBI	CHEBI:3205^Y
ChEMBL	CHEMBL1201271^N
ECHA InfoCard	100.001.317
Chemical and physical data
Formula	C₂₈H₃₃ClN₂
Molar mass	433.028 g/mol
3D model (Jmol)	Interactive image
Chirality	Racemic mixture
SMILES Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)Cc4ccc(cc4)C(C)(C)C
InChI InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3^Y Key:MOYGZHXDRJNJEP-UHFFFAOYSA-N^Y
^NY (what is this?)

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.