C16 (drug)

C16 (drug)

Identifiers
IUPAC name 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
CAS Number	608512-97-6
PubChem CID	6490494
ChemSpider	4990932
ECHA InfoCard	100.211.648
Chemical and physical data
Formula	C13H8N4OS
Molar mass	268.293 g/mol
3D model (JSmol)	Interactive image Interactive image
SMILES c4ncnc4\C=C3\c2c1scnc1ccc2NC3=O O=C\1Nc4c(C/1=C\c2cncn2)c3scnc3cc4
InChI InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3- Key:VFBGXTUGODTSPK-BAQGIRSFSA-N

C16 or PKRi is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.