CAD (gene)

CAD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BY3, 4C6B, 4C6C, 4C6D, 4C6E, 4C6F, 4C6I, 4C6J, 4C6K, 4C6L, 4C6M, 4C6N, 4C6O, 4C6P, 4C6Q, 5G1P, 5G1O, 5G1N
Identifiers
Aliases	CAD, CDG1Z, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
External IDs	MGI: 1916969 HomoloGene: 1412 GeneCards: CAD
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • amino acid binding • aspartate binding • zinc ion binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides • metal ion binding • dihydroorotase activity • ligase activity • catalytic activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • carboxyl- or carbamoyltransferase activity • identical protein binding • enzyme binding • hydrolase activity • ATP binding • aspartate carbamoyltransferase activity • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Cellular component • cytoplasm • cell projection • membrane • nuclear matrix • nucleoplasm • protein complex • terminal bouton • neuronal cell body • extracellular exosome • nucleus • cytosol Biological process • UTP biosynthetic process • response to testosterone • female pregnancy • cellular amino acid metabolic process • pyrimidine nucleoside biosynthetic process • cellular response to epidermal growth factor stimulus • heart development • cellular response to drug • glutamine metabolic process • nitrogen compound metabolic process • 'de novo' pyrimidine nucleobase biosynthetic process • animal organ regeneration • pyrimidine nucleotide biosynthetic process • response to cortisol • response to amine • drug metabolic process • protein autophosphorylation • liver development • response to caffeine • metabolic process • lactation • peptidyl-threonine phosphorylation • 'de novo' UMP biosynthetic process • response to starvation • response to insulin • citrulline biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	790	69719
Ensembl	ENSG00000084774	ENSMUSG00000013629
UniProt	P27708	B2RQC6
RefSeq (mRNA)	NM_001306079 NM_004341	NM_001289522 NM_001289523 NM_023525
RefSeq (protein)	NP_001293008 NP_004332	NP_001276451.1 NP_076014.1 NP_001276451 NP_001276452 NP_076014
Location (UCSC)	Chr 2: 27.22 – 27.24 Mb	Chr 5: 31.05 – 31.08 Mb
PubMed search

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Identifiers
Symbol	CAD
Entrez	790
HUGO	1424
OMIM	114010
RefSeq	NM_004341
UniProt	P27708
Other data
EC number	2.1.3.2
Locus	Chr. 2 p21

4BY3, 4C6B, 4C6C, 4C6D, 4C6E, 4C6F, 4C6I, 4C6J, 4C6K, 4C6L, 4C6M, 4C6N, 4C6O, 4C6P, 4C6Q, 5G1P, 5G1O, 5G1N

790

69719

ENSG00000084774

ENSMUSG00000013629

P27708

B2RQC6

...
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