CAMP receptors
| Slime mold cyclic AMP receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Dicty_CAR | ||||||||
| Pfam | PF05462 | ||||||||
| Pfam clan | CL0192 | ||||||||
| InterPro | IPR000848 | ||||||||
| PROSITE | PDOC00691 | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.
In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.
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