CCR9

Identifiers

CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28, C-C motif chemokine receptor 9

External IDs

MGI: 1341902 HomoloGene: 22546 GeneCards: CCR9

Gene ontology
Molecular function	• C-C chemokine receptor activity • G-protein coupled receptor activity • signal transducer activity • chemokine receptor activity
Cellular component	• cell surface • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane
Biological process	• positive regulation of cytosolic calcium ion concentration • chemotaxis • chemokine-mediated signaling pathway • cellular defense response • G-protein coupled receptor signaling pathway • immune response • signal transduction • CD8-positive, gamma-delta intraepithelial T cell differentiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10803


12769

Ensembl


ENSG00000173585


ENSMUSG00000029530

UniProt


P51686


Q9WUT7

RefSeq (mRNA)


NM_001256369 NM_006641 NM_031200


NM_001166625 NM_009913

RefSeq (protein)


NP_001243298 NP_006632 NP_112477


NP_001160097 NP_034043

Location (UCSC)

Chr 3: 45.89 – 45.9 Mb

Chr 9: 123.68 – 123.78 Mb

PubMed search

NM_001256369
NM_006641
NM_031200

NM_001166625
NM_009913

NP_001243298
NP_006632
NP_112477

NP_001160097
NP_034043

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.

CCR9 has also recently been designated CDw199 (cluster of differentiation w199).

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammatory conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in thymocyte recruitment and development that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described.

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