CD122

IL2RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B5I, 2ERJ, 3QAZ, 4GS7
Identifiers
Aliases	IL2RB, CD122, IL15RB, P70-75, interleukin 2 receptor subunit beta
External IDs	MGI: 96550 HomoloGene: 47955 GeneCards: IL2RB
Gene ontology Molecular function • interleukin-2 binding • protein binding • cytokine receptor activity • interleukin-2 receptor activity • Ras guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane • intracellular Biological process • protein complex assembly • negative regulation of apoptotic process • MAPK cascade • interleukin-2-mediated signaling pathway • viral process • signal transduction • positive regulation of GTPase activity • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3560	16185
Ensembl	ENSG00000100385	ENSMUSG00000068227
UniProt	P14784	P16297
RefSeq (mRNA)	NM_000878 NM_001346222 NM_001346223	NM_008368
RefSeq (protein)	NP_000869 NP_001333151 NP_001333152	NP_032394
Location (UCSC)	Chr 22: 37.13 – 37.18 Mb	Chr 15: 78.48 – 78.5 Mb
PubMed search

2B5I, 2ERJ, 3QAZ, 4GS7

3560

16185

ENSG00000100385

ENSMUSG00000068227

P14784

P16297

NM_000878
NM_001346222
NM_001346223

NM_008368

NP_000869
NP_001333151
NP_001333152

NP_032394

Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70-75.

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

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Wikipedia