CD18

ITGB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U
Identifiers
Aliases	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
External IDs	OMIM: 600065 MGI: 96611 HomoloGene: 20092 GeneCards: ITGB2
Gene ontology Molecular function • receptor activity • protein complex binding • metal ion binding • glycoprotein binding • protein binding • protein heterodimerization activity • ICAM-3 receptor activity • protein kinase binding • cell adhesion molecule binding • heat shock protein binding Cellular component • integral component of membrane • extracellular vesicle • integrin alphaL-beta2 complex • membrane • plasma membrane • receptor complex • cell surface • integrin complex • extracellular exosome • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane Biological process • leukocyte cell-cell adhesion • single organismal cell-cell adhesion • endodermal cell differentiation • toll-like receptor 4 signaling pathway • positive regulation of nitric oxide biosynthetic process • heterotypic cell-cell adhesion • cell-cell signaling • aging • receptor internalization • leukocyte migration involved in inflammatory response • natural killer cell activation • cellular response to low-density lipoprotein particle stimulus • extracellular matrix organization • receptor clustering • positive regulation of angiogenesis • neutrophil chemotaxis • cell adhesion • positive regulation of NF-kappaB transcription factor activity • regulation of cell shape • regulation of immune response • cellular extravasation • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • endothelial cell migration • leukocyte migration • regulation of peptidyl-tyrosine phosphorylation • apoptotic process • phagocytosis • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3689	16414
Ensembl	ENSG00000160255	ENSMUSG00000000290
UniProt	P05107	P11835
RefSeq (mRNA)	NM_000211 NM_001127491 NM_001303238	NM_008404
RefSeq (protein)	NP_000202 NP_001120963 NP_001290167	NP_032430.2 NP_032430
Location (UCSC)	Chr 21: 44.89 – 44.93 Mb	Chr 10: 77.53 – 77.57 Mb
PubMed search

1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U

3689

16414

ENSG00000160255

ENSMUSG00000000290

P05107

P11835

...
Wikipedia