CDC42BPA

Identifiers

CDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha

External IDs

MGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein serine/threonine kinase activity • protein kinase activity • protein binding • ATP binding • magnesium ion binding • metal ion binding • identical protein binding • kinase activity
Cellular component	• cytoplasm • actomyosin • extracellular exosome • cell leading edge • cell-cell junction
Biological process	• protein phosphorylation • actomyosin structure organization • intracellular signal transduction • cell migration • phosphorylation • actin cytoskeleton reorganization • actin cytoskeleton organization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8476


226751

Ensembl


ENSG00000143776


ENSMUSG00000026490

UniProt


Q5VT25


Q3UU96

RefSeq (mRNA)


NM_003607 NM_014826


NM_001033285 NM_001346804 NM_001346805

RefSeq (protein)


NP_003598 NP_055641


NP_001028457 NP_001333733 NP_001333734

Location (UCSC)

Chr 1: 226.99 – 227.32 Mb

Chr 1: 179.96 – 180.17 Mb

PubMed search

NM_001033285
NM_001346804
NM_001346805

NP_003598
NP_055641

NP_001028457
NP_001333733
NP_001333734

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.

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