CDKN1B

CDKN1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AST, 1H27, 1JSU
Identifiers
Aliases	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin dependent kinase inhibitor 1B
External IDs	MGI: 104565 HomoloGene: 2999 GeneCards: CDKN1B
Gene ontology Molecular function • chaperone binding • protein complex binding • transforming growth factor beta receptor, cytoplasmic mediator activity • protein kinase inhibitor activity • Hsp70 protein binding • protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • cysteine-type endopeptidase activator activity involved in apoptotic process • protein phosphatase binding Cellular component • cytoplasm • cytosol • endosome • nucleoplasm • protein complex • Cul4A-RING E3 ubiquitin ligase complex • nucleus • intracellular membrane-bounded organelle Biological process • Notch signaling pathway • mitotic cell cycle arrest • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • response to estradiol • positive regulation of cell death • response to hypoxia • response to amino acid • response to cadmium ion • positive regulation of protein catabolic process • response to organic cyclic compound • cellular response to lithium ion • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of cellular component movement • G1/S transition of mitotic cell cycle • cellular response to organic cyclic compound • response to peptide hormone • cell death • negative regulation of apoptotic process • sensory perception of sound • response to glucose • potassium ion transport • regulation of cell proliferation • negative regulation of cell growth • cell cycle arrest • negative regulation of epithelial cell proliferation involved in prostate gland development • positive regulation of cell proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of epithelial cell proliferation • positive regulation of microtubule polymerization • inner ear development • cellular response to antibiotic • cell cycle • negative regulation of phosphorylation • negative regulation of transcription, DNA-templated • activation of cysteine-type endopeptidase activity involved in apoptotic process • autophagic cell death • response to drug • negative regulation of cell proliferation • negative regulation of mitotic cell cycle • negative regulation of kinase activity • positive regulation of cell cycle • negative regulation of vascular smooth muscle cell proliferation • placenta development • regulation of exit from mitosis • regulation of lens fiber cell differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1027	12576
Ensembl	ENSG00000111276	ENSMUSG00000003031
UniProt	P46527	P46414
RefSeq (mRNA)	NM_004064	NM_009875
RefSeq (protein)	NP_004055	NP_034005.2 NP_034005
Location (UCSC)	Chr 12: 12.72 – 12.72 Mb	Chr 6: 134.92 – 134.93 Mb
PubMed search

2AST, 1H27, 1JSU

1027

12576

ENSG00000111276

ENSMUSG00000003031

P46527

P46414

NM_004064

NM_009875

NP_004055

NP_034005.2
NP_034005

Cyclin-dependent kinase inhibitor 1B (p27^Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.

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