CFLAR

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3H11, 3H13, 2N5R

Identifiers

Aliases

CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator

External IDs

MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR

Gene ontology
Molecular function	• death receptor binding • cysteine-type peptidase activity • protein complex binding • protease binding • protein binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis • enzyme activator activity • cysteine-type endopeptidase activity
Cellular component	• cytoplasm • cytosol • CD95 death-inducing signaling complex • ripoptosome • death-inducing signaling complex • membrane raft
Biological process	• regulation of apoptotic process • execution phase of apoptosis • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • proteolysis • skeletal myofibril assembly • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • negative regulation of myoblast fusion • skeletal muscle atrophy • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of necroptotic process • regulation of extrinsic apoptotic signaling pathway via death domain receptors • viral process • regulation of skeletal muscle satellite cell proliferation • skeletal muscle tissue development • apoptotic process • positive regulation of catalytic activity • response to hypoxia • negative regulation of cardiac muscle cell apoptotic process • positive regulation of neuron projection development • cellular response to insulin stimulus • response to testosterone • positive regulation of ERK1 and ERK2 cascade • cellular response to epidermal growth factor stimulus • cellular response to estradiol stimulus • cellular response to hypoxia • cellular response to dexamethasone stimulus • cellular response to nitric oxide • positive regulation of glomerular mesangial cell proliferation • positive regulation of extracellular matrix organization • negative regulation of reactive oxygen species biosynthetic process • negative regulation of cellular response to transforming growth factor beta stimulus • negative regulation of hepatocyte apoptotic process • negative regulation of epithelial cell apoptotic process • positive regulation of hepatocyte proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8837


12633

Ensembl


ENSG00000003402


ENSMUSG00000026031

UniProt


O15519


O35732

RefSeq (mRNA)

NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517
NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879


NM_001289704 NM_001293804 NM_001293805 NM_009805 NM_207653

RefSeq (protein)

NP_001120655 NP_001120656 NP_001189444 NP_001189445 NP_001189446
NP_001189447 NP_001189448 NP_001294971 NP_001294972 NP_003870

NP_001276633.1 NP_997536.1 NP_001276633 NP_001280733 NP_001280734
NP_033935 NP_997536

Location (UCSC)

Chr 2: 201.12 – 201.18 Mb

Chr 1: 58.71 – 58.76 Mb

PubMed search

3H11, 3H13, 2N5R

NM_001202518
NM_001202519
NM_001308042
NM_001308043
NM_003879

NM_001289704
NM_001293804
NM_001293805
NM_009805
NM_207653

NP_001189447
NP_001189448
NP_001294971
NP_001294972
NP_003870

...
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