COBRA1

NELFB
Identifiers
Aliases	NELFB, COBRA1, NELF-B, Cofactor of BRCA1, negative elongation factor complex member B
External IDs	MGI: 1931035 HomoloGene: 121600 GeneCards: NELFB
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 137,255,173 bp End 137,273,546 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band n/a Start 25,199,712 bp End 25,211,489 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • RNA binding Cellular component • nucleus • cytoplasm • NELF complex • nucleoplasm Biological process • transcription elongation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of viral transcription • negative regulation of transcription elongation from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25920	58202
Ensembl	ENSG00000188986	ENSMUSG00000013465
UniProt	Q8WX92	Q8C4Y3
RefSeq (mRNA)	NM_015456	NM_021393 NM_001310157
RefSeq (protein)	NP_056271	NP_001297086 NP_067368
Location (UCSC)	Chr 9: 137.26 – 137.27 Mb	Chr 9: 25.2 – 25.21 Mb
PubMed search

25920

58202

ENSG00000188986

ENSMUSG00000013465

Q8WX92

Q8C4Y3

NM_015456

NM_021393
NM_001310157

NP_056271

NP_001297086
NP_067368

Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B.

NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660). COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.

Cofactor of BRCA1 has been shown to interact with:

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Wikipedia