COL2A1

COL2A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1U5M, 2FSE, 2SEB
Identifiers
Aliases	COL2A1, ANFH, AOM, COL11A3, SEDC, STL1, collagen type II alpha 1, collagen type II alpha 1 chain
External IDs	OMIM: 120140 MGI: 88452 HomoloGene: 55607 GeneCards: COL2A1
Gene ontology Molecular function • identical protein binding • platelet-derived growth factor binding • extracellular matrix structural constituent conferring tensile strength • extracellular matrix structural constituent • metal ion binding Cellular component • endoplasmic reticulum lumen • collagen type II trimer • collagen trimer • extracellular matrix • cytoplasm • proteinaceous extracellular matrix • extracellular region • basement membrane • extracellular space Biological process • proteoglycan metabolic process • central nervous system development • endochondral ossification • chondrocyte differentiation • collagen fibril organization • ossification • limb morphogenesis • otic vesicle development • notochord development • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • heart morphogenesis • inner ear morphogenesis • inner ear development • tissue homeostasis • regulation of immune response • cartilage development involved in endochondral bone morphogenesis • sensory perception of sound • skeletal system development • collagen catabolic process • regulation of gene expression • bone development • extracellular matrix organization • skeletal system morphogenesis • cellular response to BMP stimulus • visual perception • palate development • embryonic skeletal joint morphogenesis • cartilage development • limb bud formation • cartilage condensation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1280	12824
Ensembl	ENSG00000139219	ENSMUSG00000022483
UniProt	P02458	P28481
RefSeq (mRNA)	NM_001844 NM_033150	NM_001113515 NM_031163
RefSeq (protein)	NP_001835 NP_149162	NP_001106987.2 NP_112440.2 NP_001106987 NP_112440
Location (UCSC)	Chr 12: 47.97 – 48 Mb	Chr 15: 97.98 – 98 Mb
PubMed search

1U5M, 2FSE, 2SEB

1280

12824

ENSG00000139219

ENSMUSG00000022483

P02458

P28481

NM_001844
NM_033150

NM_001113515
NM_031163

NP_001835
NP_149162

NP_001106987.2
NP_112440.2
NP_001106987
NP_112440

Collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital), also known as COL2A1, is a human gene that provides instructions for the production of the pro-alpha1(II) chain of type II collagen.

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