COQ6

COQ6
Identifiers
Aliases	COQ6, CGI10, COQ10D6, CGI-10, coenzyme Q6, monooxygenase
External IDs	MGI: 1924408 HomoloGene: 6039 GeneCards: COQ6
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.3 Start 73,949,926 bp End 73,963,670 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 D1 Start 84,361,657 bp End 84,373,796 bp
Gene ontology Molecular function • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • FAD binding • flavin adenine dinucleotide binding • monooxygenase activity Cellular component • mitochondrial inner membrane • Golgi apparatus • cell projection • membrane • mitochondrion Biological process • oxidation-reduction process • ubiquinone biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51004	217707
Ensembl	ENSG00000119723	ENSMUSG00000021235
UniProt	Q9Y2Z9	Q8R1S0
RefSeq (mRNA)	NM_182476 NM_182480	NM_172582
RefSeq (protein)	NP_872282 NP_872286	NP_766170
Location (UCSC)	Chr 14: 73.95 – 73.96 Mb	Chr 12: 84.36 – 84.37 Mb
PubMed search

51004

217707

ENSG00000119723

ENSMUSG00000021235

Q9Y2Z9

Q8R1S0

NM_182476
NM_182480

NM_172582

NP_872282
NP_872286

NP_766170

Coenzyme Q6 monooxygenase is a protein that in humans is encoded by the COQ6 gene.

The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis.

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Wikipedia