CRLF3

CRLF3
Identifiers
Aliases	CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDs	MGI: 1860086 HomoloGene: 9327 GeneCards: CRLF3
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 30,769,388 bp End 30,824,776 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 47.43 cM Start 80,046,493 bp End 80,080,991 bp
Gene ontology Molecular function • protein binding • identical protein binding Cellular component • plasma membrane • cytoplasm • cytosol Biological process • negative regulation of cell growth • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cell cycle arrest • G1/S transition of mitotic cell cycle • positive regulation of JAK-STAT cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51379	54394
Ensembl	ENSG00000176390	ENSMUSG00000017561
UniProt	Q8IUI8	Q9Z2L7
RefSeq (mRNA)	NM_015986	NM_001277106 NM_018776
RefSeq (protein)	NP_057070	NP_001264035 NP_061246
Location (UCSC)	Chr 17: 30.77 – 30.82 Mb	Chr 17: 80.05 – 80.08 Mb
PubMed search

51379

54394

ENSG00000176390

ENSMUSG00000017561

Q8IUI8

Q9Z2L7

NM_015986

NM_001277106
NM_018776

NP_057070

NP_001264035
NP_061246

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.

Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called Crlf3^{tm1a(KOMP)Wtsi} was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and two significant phenotypes were reported. Homozygous mutant female adults had a significant increase in circulating levels of fructosamine, while mutants of both sexes had decreased platelet cell numbers.

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