CSF3R

CSF3R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9Q
Identifiers
Aliases	CSF3R, CD114, GCSFR, colony stimulating factor 3 receptor, SCN7
External IDs	OMIM: 138971 MGI: 1339755 HomoloGene: 601 GeneCards: CSF3R
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 36,466,043 bp End 36,483,278 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 59.77 cM Start 126,024,550 bp End 126,044,440 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine receptor activity • protein binding • granulocyte colony-stimulating factor binding • signaling receptor activity Cellular component • integral component of membrane • extracellular region • integral component of plasma membrane • membrane • plasma membrane Biological process • defense response • cell adhesion • regulation of myeloid cell differentiation • neutrophil chemotaxis • signal transduction • amelogenesis • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1441	12986
Ensembl	ENSG00000119535	ENSMUSG00000028859
UniProt	Q99062	P40223
RefSeq (mRNA)	NM_000760 NM_156038 NM_156039 NM_172313	NM_001252651 NM_007782
RefSeq (protein)	NP_000751 NP_724781 NP_758519	NP_001239580 NP_031808
Location (UCSC)	Chr 1: 36.47 – 36.48 Mb	Chr 4: 126.02 – 126.04 Mb
PubMed search

2D9Q

1441

12986

ENSG00000119535

ENSMUSG00000028859

Q99062

P40223

NM_000760
NM_156038
NM_156039
NM_172313

NM_001252651
NM_007782

NP_000751
NP_724781
NP_758519

NP_001239580
NP_031808

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

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