CUL4A

CUL4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HYE, 4A0K
Identifiers
Aliases	CUL4A
External IDs	MGI: 1914487 HomoloGene: 81724 GeneCards: CUL4A
Gene ontology Molecular function • ubiquitin protein ligase activity • ubiquitin protein ligase binding • protein binding Cellular component • nucleoplasm • Cul4-RING E3 ubiquitin ligase complex • cullin-RING ubiquitin ligase complex • Cul4A-RING E3 ubiquitin ligase complex Biological process • ubiquitin-dependent protein catabolic process • negative regulation of granulocyte differentiation • nucleotide-excision repair, DNA damage recognition • negative regulation of cell proliferation • positive regulation of G1/S transition of mitotic cell cycle • intrinsic apoptotic signaling pathway • regulation of protein metabolic process • somatic stem cell population maintenance • nucleotide-excision repair, DNA incision • viral process • cell cycle arrest • transcription-coupled nucleotide-excision repair • hemopoiesis • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of cell proliferation • DNA damage response, detection of DNA damage • cellular response to DNA damage stimulus • protein ubiquitination • regulation of DNA damage checkpoint • global genome nucleotide-excision repair • in utero embryonic development • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • G1/S transition of mitotic cell cycle • regulation of nucleotide-excision repair • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, preincision complex stabilization • DNA repair • nucleotide-excision repair, DNA duplex unwinding • nucleotide-excision repair, preincision complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8451	99375
Ensembl	ENSG00000139842	ENSMUSG00000031446
UniProt	Q13619	Q3TCH7
RefSeq (mRNA)	NM_001008895 NM_001278513 NM_001278514 NM_003589	NM_146207
RefSeq (protein)	NP_001008895 NP_001265442 NP_001265443 NP_003580	NP_666319.2 NP_666319
Location (UCSC)	Chr 13: 113.21 – 113.27 Mb	Chr 8: 13.11 – 13.15 Mb
PubMed search

2HYE, 4A0K

8451

99375

ENSG00000139842

ENSMUSG00000031446

Q13619

Q3TCH7

NM_001008895
NM_001278513
NM_001278514
NM_003589

NM_146207

NP_001008895
NP_001265442
NP_001265443
NP_003580

NP_666319.2
NP_666319

Cullin-4A is a protein that in humans is encoded by the CUL4A gene. CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. Interestingly, a component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.

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Wikipedia