Caldesmon

CALD1
Identifiers
Aliases	CALD1, CDM, H-CAD, HCAD, L-CAD, LCAD, NAG22, caldesmon 1
External IDs	HomoloGene: 137424 GeneCards: CALD1
Gene ontology Molecular function • myosin binding • actin binding • tropomyosin binding • protein binding • calmodulin binding • cadherin binding Cellular component • cytoplasm • cytosol • plasma membrane • myofibril • cytoskeleton • actin cytoskeleton • intracellular membrane-bounded organelle • membrane • actin cap Biological process • movement of cell or subcellular component • muscle contraction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	800	n/a
Ensembl	ENSG00000122786	n/a
UniProt	Q05682	n/a
RefSeq (mRNA)	NM_004342 NM_033138 NM_033139 NM_033140 NM_033157	n/a
RefSeq (protein)	NP_004333 NP_149129 NP_149130 NP_149131 NP_149347	n/a
Location (UCSC)	Chr 7: 134.74 – 134.97 Mb	n/a
PubMed search		n/a

800

n/a

ENSG00000122786

n/a

Q05682

n/a

NM_004342
NM_033138
NM_033139
NM_033140
NM_033157

n/a

NP_004333
NP_149129
NP_149130
NP_149131
NP_149347

n/a

Caldesmon is a protein that in humans is encoded by the CALD1 gene.

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca⁺⁺-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca⁺⁺-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

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Wikipedia