Calsenilin

KCNIP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E6W
Identifiers
Aliases	KCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDs	MGI: 1929258 HomoloGene: 8382 GeneCards: KCNIP3
Gene ontology Molecular function • DNA binding • calcium ion binding • sequence-specific DNA binding • potassium channel activity • transcription corepressor activity • ion channel binding • voltage-gated ion channel activity • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • potassium channel regulator activity Cellular component • cytoplasm • axon terminus • cytosol • Golgi apparatus • membrane • voltage-gated potassium channel complex • axon • dendrite • protein-DNA complex • endoplasmic reticulum • nucleus • plasma membrane Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • regulation of ion transmembrane transport • negative regulation of transcription from RNA polymerase II promoter • ion transport • GO:0006350 transcription, DNA-templated • potassium ion transport • cardiac conduction • potassium ion transmembrane transport • transport • protein localization to plasma membrane • intracellular protein transport • regulation of potassium ion transmembrane transport • signal transduction • apoptotic process • negative regulation of nucleic acid-templated transcription • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30818	56461
Ensembl	ENSG00000115041	ENSMUSG00000079056
UniProt	Q9Y2W7	Q9QXT8 P0C092
RefSeq (mRNA)	NM_001034914 NM_013434	NM_001111331 NM_001291005 NM_019789
RefSeq (protein)	NP_001030086 NP_038462	NP_001104801.1 NP_001277934.1 NP_062763.2 NP_001104801 NP_001277934 NP_062763
Location (UCSC)	Chr 2: 95.3 – 95.39 Mb	Chr 2: 127.46 – 127.52 Mb
PubMed search

2E6W

30818

56461

ENSG00000115041

ENSMUSG00000079056

Q9Y2W7

Q9QXT8
P0C092

NM_001034914
NM_013434

NM_001111331
NM_001291005
NM_019789

NP_001030086
NP_038462

NP_062763

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling.Alternatively spliced transcript variants encoding different isoforms have been described.

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