Carlo of Naples and Sicily (Italian: Carlo Tito Francesco Giuseppe; 4 January 1775 – 17 December 1778) was Duke of Calabria as heir to Naples and Sicily.

Born at the Caserta Palace near Naples, he was known as the Duke of Calabria at birth as the heir apparent to his father's throne. His mother was a daughter of Empress Maria Theresa and thus sister of Marie Antoinette.

A member of the House of Bourbon, he was a prince of Naples and Sicily by birth. He was the hereditary prince of Naples. His birth allowed his mother to have a place in the Council of State, part of his parents' marriage contract.

Carlo died of smallpox aged 3. Two of his younger siblings would die of smallpox also the said Princess Maria Cristina Amelia who caught it from Prince Giuseppe the two dying within a week of each other.

He was buried at the Church of Santa Chiara in Naples.

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