Cholesterol 7α-hydroxylase

CYP7A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DAX, 3SN5, 3V8D
Identifiers
Aliases	CYP7A1, CP7A, CYP7, CYPVII, cytochrome P450 family 7 subfamily A member 1
External IDs	OMIM: 118455 MGI: 106091 HomoloGene: 30987 GeneCards: CYP7A1
Gene location (Human) Chr. Chromosome 8 (human) Band 8q12.1 Start 58,490,178 bp End 58,500,236 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A1 Start 6,265,612 bp End 6,275,633 bp
Gene ontology Molecular function • iron ion binding • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • cholesterol 7-alpha-monooxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum Biological process • steroid metabolic process • lipid metabolic process • cholesterol metabolic process • cholesterol catabolic process • cellular response to cholesterol • regulation of bile acid biosynthetic process • sterol metabolic process • cholesterol homeostasis • bile acid biosynthetic process • oxidation-reduction process • cellular response to glucose stimulus • regulation of lipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1581	13122
Ensembl	ENSG00000167910	ENSMUSG00000028240
UniProt	P22680	Q64505
RefSeq (mRNA)	NM_000780	NM_007824
RefSeq (protein)	NP_000771	NP_031850
Location (UCSC)	Chr 8: 58.49 – 58.5 Mb	Chr 8: 6.27 – 6.28 Mb
PubMed search

3DAX, 3SN5, 3V8D

1581

13122

ENSG00000167910

ENSMUSG00000028240

P22680

Q64505

NM_000780

NM_007824

NP_000771

NP_031850

Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene which has an important role in cholesterol metabolism. It is a enzyme, which belongs to the oxidoreductase class, and converts cholesterol to 7-alpha-hydroxycholesterol, the first and rate limiting step in bile acid synthesis.

The inhibition of cholesterol 7-alpha-hydroxylase (CYP7A1) represses bile acid biosynthesis.

Sequence comparisons indicated a huge similarity between cytochromes P450 identified in man and bacteria, and suggested that the superfamily Cytochrome P450 first originated from a common ancestral gene some three billion years ago.

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Wikipedia