Clorgiline

Clorgiline
Clinical data

ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine
CAS Number	17780-72-2^Y
PubChem CID	4380
IUPHAR/BPS	6636
DrugBank	DB04017^Y
ChemSpider	4227^Y
UNII	LYJ16FZU9Q
KEGG	D03248^Y
ChEBI	CHEBI:3763^N
ChEMBL	CHEMBL8706^Y
Chemical and physical data
Formula	C₁₃H₁₅Cl₂NO
Molar mass	272.17 g/mol
3D model (JSmol)	Interactive image
SMILES Clc1cc(Cl)ccc1OCCCN(CC#C)C
InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3^Y Key:BTFHLQRNAMSNLC-UHFFFAOYSA-N^Y
^NY (what is this?)

Clorgiline (INN), or clorgyline (BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research. It has been found to bind with high affinity to the σ₁ receptor (K_i = 3.2 nM) and with very high affinity to the I₂ imidazoline receptor (K_i = 40 pM).