Complex III
| UCR_TM | |||||||||
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Crystal structure of mitochondrial cytochrome bc1 complex bound with ubiquinone.
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| Identifiers | |||||||||
| Symbol | UCR_TM | ||||||||
| Pfam | PF02921 | ||||||||
| InterPro | IPR004192 | ||||||||
| SCOP | 1be3 | ||||||||
| SUPERFAMILY | 1be3 | ||||||||
| TCDB | 3.D.3 | ||||||||
| OPM superfamily | 345 | ||||||||
| OPM protein | 3cx5 | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| ubiquinol—cytochrome-c reductase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.10.2.2 | ||||||||
| CAS number | 9027-03-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
The coenzyme Q : cytochrome c — oxidoreductase, sometimes called the cytochrome bc1 complex, and at other times complex III, is the third complex in the electron transport chain (EC 1.10.2.2), playing a critical role in biochemical generation of ATP (oxidative phosphorylation). Complex III is a multisubunit transmembrane protein encoded by both the mitochondrial () and the nuclear genomes (all other subunits). Complex III is present in the of all animals and all aerobic eukaryotes and the inner membranes of most eubacteria. Mutations in Complex III cause exercise intolerance as well as multisystem disorders. The bc1 complex contains 11 subunits, 3 respiratory subunits (cytochrome B, C1, Rieske protein), 2 core proteins and 6 low-molecular weight proteins.
Ubiquinol—cytochrome-c reductase catalyzes the chemical reaction
Thus, the two substrates of this enzyme are quinol (QH2) and ferri- (Fe3+) , whereas its 3 products are quinone (Q), ferro- (Fe2+) cytochrome c, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with a cytochrome as acceptor. This enzyme participates in oxidative phosphorylation. It has four cofactors: , , and a 2-Iron ferredoxin of the Rieske type.
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