Cortactin

CTTN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X69, 2D1X
Identifiers
Aliases	CTTN, EMS1, cortactin
External IDs	OMIM: 164765 MGI: 99695 HomoloGene: 3834 GeneCards: CTTN
Gene ontology Molecular function • profilin binding • protein binding • cadherin binding Cellular component • cytoplasm • Golgi apparatus • cell projection • intracellular membrane-bounded organelle • membrane • focal adhesion • growth cone • ruffle • voltage-gated potassium channel complex • cortical cytoskeleton • plasma membrane • dendritic spine • mitotic spindle midzone • cell junction • dendrite • cell cortex • actin filament • podosome • clathrin-coated pit • extracellular exosome • cytoskeleton • lamellipodium • cytosol Biological process • actin cytoskeleton reorganization • neuron projection morphogenesis • endocytosis • positive regulation of actin filament polymerization • regulation of axon extension • cell motility • substrate-dependent cell migration, cell extension • negative regulation of extrinsic apoptotic signaling pathway • receptor-mediated endocytosis • dendritic spine maintenance • focal adhesion assembly • actin filament polymerization • regulation of mitophagy • lamellipodium organization • intracellular protein transport • positive regulation of smooth muscle contraction • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2017	13043
Ensembl	ENSG00000085733	ENSMUSG00000031078
UniProt	Q14247	Q60598
RefSeq (mRNA)	NM_001184740 NM_005231 NM_138565	NM_001252572 NM_007803
RefSeq (protein)	NP_001171669 NP_005222 NP_612632	NP_031829.2 NP_001239501 NP_031829
Location (UCSC)	Chr 11: 70.4 – 70.44 Mb	Chr 7: 144.44 – 144.47 Mb
PubMed search

1X69, 2D1X

2017

13043

ENSG00000085733

ENSMUSG00000031078

Q14247

Q60598

NM_001184740
NM_005231
NM_138565

NM_001252572
NM_007803

NP_001171669
NP_005222
NP_612632

NP_031829.2
NP_001239501
NP_031829

Cortactin (from “cortical actin binding protein”) is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.

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Wikipedia