| State Road 59 | ||||
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| Maintained by FDOT | ||||
| Length: | 25.919 mi (41.713 km) | |||
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State Road 59 (SR 59) runs north to south through the eastern Florida Panhandle, with a northern terminus at US 90 near Lloyd, and a southern terminus at US 98 in rural Jefferson County.
The route is extended at both ends by county roads; to the north through Leon County to the Georgia state line, where it becomes State Route 122 to Thomasville; and on the south via County Road 59, a former secondary state route, into the Saint Marks National Wildlife Refuge.