Crm1

XPO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS
Identifiers
Aliases	XPO1, CRM1, emb, exp1, exportin 1
External IDs	MGI: 2144013 HomoloGene: 2554 GeneCards: XPO1
Gene ontology Molecular function • protein domain specific binding • transporter activity • Ran GTPase binding • protein transporter activity • protein binding • RNA binding • nucleocytoplasmic transporter activity • nuclear export signal receptor activity Cellular component • cytoplasm • Cajal body • nuclear membrane • membrane • intracellular membrane-bounded organelle • nuclear envelope • intracellular ribonucleoprotein complex • nucleoplasm • annulate lamellae • Q40260 • kinetochore • nucleolus • cytosol • host cell • protein complex • intracellular Biological process • ribosomal small subunit export from nucleus • intracellular transport of virus • regulation of centrosome duplication • mRNA transport • regulation of mRNA stability • negative regulation of transcription from RNA polymerase II promoter • protein export from nucleus • regulation of protein catabolic process • protein localization to nucleus • protein transport • ribosomal large subunit export from nucleus • intracellular protein transport • viral process • response to drug • sister chromatid cohesion • ribosomal subunit export from nucleus • regulation of protein export from nucleus • ribosome biogenesis • transport • nucleocytoplasmic transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7514	103573
Ensembl	ENSG00000082898	ENSMUSG00000020290
UniProt	O14980	Q6P5F9
RefSeq (mRNA)	NM_003400	NM_001035226 NM_134014
RefSeq (protein)	NP_003391	NP_001030303 NP_598775
Location (UCSC)	Chr 2: 61.48 – 61.54 Mb	Chr 11: 23.26 – 23.3 Mb
PubMed search

1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS

7514

103573

ENSG00000082898

ENSMUSG00000020290

O14980

Q6P5F9

NM_003400

NM_001035226
NM_134014

NP_003391

NP_001030303
NP_598775

Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is an eukaryotic protein that mediates the nuclear export of proteins, rRNA, snRNA, and some mRNA.

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