Cytidine deaminase

CDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ0
Identifiers
Aliases	CDA, CDD, cytidine deaminase
External IDs	MGI: 1919519 HomoloGene: 1352 GeneCards: CDA
Gene ontology Molecular function • protein homodimerization activity • nucleoside binding • cytidine deaminase activity • zinc ion binding • metal ion binding • protein binding • catalytic activity • identical protein binding • hydrolase activity Cellular component • cytosol • extracellular region • secretory granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • cytosine metabolic process • pyrimidine nucleoside salvage • cell surface receptor signaling pathway • cytidine deamination • negative regulation of cell growth • pyrimidine-containing compound salvage • negative regulation of nucleotide metabolic process • protein homotetramerization • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	978	72269
Ensembl	ENSG00000158825	ENSMUSG00000028755
UniProt	P32320	P56389
RefSeq (mRNA)	NM_001785	NM_028176
RefSeq (protein)	NP_001776	NP_082452.1 NP_082452
Location (UCSC)	Chr 1: 20.59 – 20.62 Mb	Chr 4: 138.34 – 138.37 Mb
PubMed search

1MQ0

978

72269

ENSG00000158825

ENSMUSG00000028755

P32320

P56389

NM_001785

NM_028176

NP_001776

NP_082452.1
NP_082452

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

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