DDX20

DDX20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OXC, 3B7G
Identifiers
Aliases	DDX20, DP103, GEMIN3, DEAD-box helicase 20
External IDs	MGI: 1858415 HomoloGene: 5214 GeneCards: DDX20
Gene ontology Molecular function • DNA binding • protein binding, bridging • nucleotide binding • ATP-dependent RNA helicase activity • helicase activity • protein domain specific binding • histone deacetylase binding • protein binding • nucleic acid binding • repressing transcription factor binding • hydrolase activity • ATP binding Cellular component • SMN-Sm protein complex • cytosol • membrane • transcriptional repressor complex • nucleoplasm • SMN complex • RNA polymerase II transcription repressor complex • cytoskeleton • nucleus • Gemini of coiled bodies • cytoplasm • nuclear body • nucleolus Biological process • RNA processing • spliceosomal tri-snRNP complex assembly • mRNA processing • regulation of steroid biosynthetic process • negative regulation of transcription from RNA polymerase II promoter • oogenesis • spliceosomal snRNP assembly • RNA secondary structure unwinding • RNA splicing • positive regulation of apoptotic process • negative regulation of transcription, DNA-templated • negative regulation of cell proliferation • nuclear import Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11218	53975
Ensembl	ENSG00000064703	ENSMUSG00000027905
UniProt	Q9UHI6	Q9JJY4
RefSeq (mRNA)	NM_007204	NM_017397
RefSeq (protein)	NP_009135	NP_059093
Location (UCSC)	Chr 1: 111.76 – 111.77 Mb	Chr 3: 105.68 – 105.69 Mb
PubMed search

2OXC, 3B7G

11218

53975

ENSG00000064703

ENSMUSG00000027905

Q9UHI6

Q9JJY4

NM_007204

NM_017397

NP_009135

NP_059093

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neuron (SMN) complex. This DEAD box protein is one of the gem-associated proteins (GEMIN3) that interacts directly with SMN. SMN is the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.

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Wikipedia