DGKD

DGKD
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1R79, 3BQ7
Identifiers
Aliases	DGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta
External IDs	MGI: 2138334 HomoloGene: 100054 GeneCards: DGKD
Gene ontology Molecular function • transferase activity • nucleotide binding • diacylglycerol kinase activity • protein homodimerization activity • metal ion binding • kinase activity • protein binding • diacylglycerol binding • protein heterodimerization activity • ATP binding • NAD+ kinase activity Cellular component • cytoplasm • membrane • plasma membrane • nucleus • cytosol • cytoplasmic vesicle Biological process • intracellular signal transduction • endocytosis • epidermal growth factor receptor signaling pathway • phosphorylation • response to organic substance • platelet activation • multicellular organism development • cell growth • protein kinase C-activating G-protein coupled receptor signaling pathway • diacylglycerol metabolic process • protein transport • second-messenger-mediated signaling • protein homooligomerization • signal transduction • lipid phosphorylation • metabolism • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8527	227333
Ensembl	n/a	ENSMUSG00000070738
UniProt	Q16760	n/a
RefSeq (mRNA)	NM_003648 NM_152879	NM_177646
RefSeq (protein)	NP_003639 NP_690618	n/a
Location (UCSC)	n/a	Chr 1: 87.85 – 87.95 Mb
PubMed search

1R79, 3BQ7

8527

227333

n/a

ENSMUSG00000070738

Q16760

n/a

NM_003648
NM_152879

NM_177646

NP_003639
NP_690618

n/a

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.

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