DGKG

Identifiers

DGKG, DAGK3, DGK-GAMMA, diacylglycerol kinase gamma

External IDs

MGI: 105060 HomoloGene: 1029 GeneCards: DGKG

Gene ontology
Molecular function	• transferase activity • nucleotide binding • calcium ion binding • ATP binding • metal ion binding • kinase activity • diacylglycerol kinase activity • NAD+ kinase activity
Cellular component	• cytoplasm • plasma membrane • membrane
Biological process	• platelet activation • protein kinase C-activating G-protein coupled receptor signaling pathway • intracellular signal transduction • neuron development • phosphorylation • signal transduction • glycerolipid metabolic process • lipid phosphorylation • metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1608


110197

Ensembl


ENSG00000058866


ENSMUSG00000022861

UniProt


P49619


Q91WG7

RefSeq (mRNA)


NM_001346 NM_001080744 NM_001080745


NM_138650 NM_001346673

RefSeq (protein)


NP_001074213 NP_001074214 NP_001337


NP_001333602 NP_619591

Location (UCSC)

Chr 3: 186.11 – 186.36 Mb

Chr 16: 22.47 – 22.66 Mb

PubMed search

NM_001346
NM_001080744
NM_001080745

NM_138650
NM_001346673

NP_001074213
NP_001074214
NP_001337

NP_001333602
NP_619591

Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene.

This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.

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